2-Fluorophenyl isothiocyanate → 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

HRID 544490

반응식

HRID 544490 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[S:22]>CCOCC>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:22]

참가 물질

4

반응물 2

HCID 975202-Fluorophenyl isothiocyanateHCID 27346391-Piperazinylpyrazine

생성물 1

HCID 133186942'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 4.59 g. of 2-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether over a period of 10 minutes. The mixture is stirred for 30 minutes and the resulting solid is collectedand then recrystallized from 200 ml. of ethanol, giving 7.04 g. of the desired product, m.p. 151°-153° C.

후처리

  1. customthen recrystallized from 200 ml
  2. customof ethanol, giving 7.04 g

출처 및 근거

ORD 기록
ord-b8ccbe605ef04daf82a06593a3331c0c
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450272

연결된 노트

불러오는 중…