Methanol → 2-Oxo-4,6-dipropyl-1,2-dihydropyridine-3-carbonitrile

HRID 544550

반응식

HRID 544550 반응식
[CH3:1][CH2:2][CH2:3][C:4](=O)[CH2:5][C:6](=O)[CH2:7][CH2:8][CH3:9].CO.[C:14]([CH2:16][C:17]([NH2:19])=[O:18])#[N:15].C[O-].[Na+]>O.C(O)(=O)C>[C:14]([C:16]1[C:17](=[O:18])[NH:19][C:6]([CH2:7][CH2:8][CH3:9])=[CH:5][C:4]=1[CH2:3][CH2:2][CH3:1])#[N:15]

참가 물질

7

반응물 4

HCID 887MethanolHCID 7898CyanoacetamideHCID 264544,6-NonanedioneHCID 10942334Sodium Methoxide

생성물 1

HCID 132990072-Oxo-4,6-dipropyl-1,2-dihydropyridine-3-carbonitrile수율 81.9%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

3-Cyano-4,6-di-n-propyl-2(1H)-pyridinone was prepared as follows: A mixture containing 15.6 g of 4,6-nonanedione, 200 ml of methanol, 10 g of cyanoacetamide and 6 g of sodium methoxide was refluxed with stirring for 22 hours and then stripped to dryness in vacuo. The residue was dissolved in 100 ml of water and the solution acidified with acetic acid. The white precipitate was collected, washed with water, air-dried, recrystallized from isopropyl alcohol-n-hexane and dried in vacuo at 80°-85° C. to produce 16.7 g of 3-cyano-4,6-di-n-propyl-2(1H)-pyridinone, m.p. 151°-152° C.

후처리

  1. custom3-Cyano-4,6-di-n-propyl-2(1H)-pyridinone was prepared
  2. temperaturewas refluxed
  3. customThe white precipitate was collected
  4. washwashed with water
  5. customair-dried
  6. customrecrystallized from isopropyl alcohol-n-hexane
  7. customdried in vacuo at 80°-85° C.

출처 및 근거

ORD 기록
ord-df17b0cc4947456784a3aa58265e2ed9
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04451469

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