Phenyl Isothiocyanate → 1-(4-Hydroxybutyl)-3-(3-phenylthioureido)pyrazole
반응식
[NH2:1][C:2]1[CH:6]=[CH:5][N:4]([CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[N:3]=1.[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(#N)C>[OH:11][CH2:10][CH2:9][CH2:8][CH2:7][N:4]1[CH:5]=[CH:6][C:2]([NH:1][C:19]([NH:18][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[S:20])=[N:3]1참가 물질
4
실험 절차
To a solution of 3-amino-1-(4-hydroxybutyl)pyrazole (1.0 g.) in dry acetonitrile (3 ml.) was slowly added phenylisothiocyanate (0.95 g.) and the mixture was stirred at room temperature for 17 hours. The solvent was evaporated and the residue purified by column chromatography on silica gel using EtOAc as eluant to give 1-(4-hydroxybutyl)-3-(3-phenylthioureido)pyrazole (0.54 g.; 29%), m.p. 112°-117°.
후처리
- customThe solvent was evaporated
- customthe residue purified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-bb1c2e5ff6a449c18db79a5c178c6732
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04451463
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