Acetic Acid → 5-[7-(4-Carboxyphenoxy)heptyl]-3-methylisoxazole

HRID 544610노트

반응식

HRID 544610 반응식
C(C1[CH:22]=[CH:21][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([CH3:20])[CH:16]=2)=[CH:5][CH:4]=1)#N.Cl.[C:24]([OH:27])(=[O:26])[CH3:25]>O>[C:24]([C:25]1[CH:22]=[CH:21][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[O:19][N:18]=[C:17]([CH3:20])[CH:16]=2)=[CH:5][CH:4]=1)([OH:27])=[O:26]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 52712085-[7-(4-Cyanophenoxy)heptyl]-3-methylisoxazole

생성물 1

HCID 52712095-[7-(4-Carboxyphenoxy)heptyl]-3-methylisoxazole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3.0 g (0.01 mole) of 5-[7-(4-cyanophenoxy)heptyl]-3-methylisoxazole (Example 5), 20 ml of 20% aqueous hydrochloric acid and 20 ml of glacial acetic acid was heated at reflux for 19 hours. The reaction mixture was cooled, 20 ml of water added, and the solid product collected by filtration to give 3.0 g of 5-[7-(4-carboxyphenoxy)heptyl]-3-methylisoxazole as a colorless solid, m.p. 129°-130° C.; MIC vs. rhinovirus Type 2 in vitro=10 μg/ml.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 19 hours
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe solid product collected by filtration

출처 및 근거

ORD 기록
ord-707ade732cdf4e6d862277323e126b53
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04451476

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