3-Amino-1-propanol → 5-[2-[3-(Hydroxy)propylcarbamoyloxy]ethylthio]imdazo[1,2-a]pyridine

HRID 5447

반응식

HRID 5447 반응식
O([C:8]([O:10][CH2:11][CH2:12][S:13][C:14]1[N:19]2[CH:20]=[CH:21][N:22]=[C:18]2[CH:17]=[CH:16][CH:15]=1)=[O:9])C1C=CC=CC=1.[NH2:23][CH2:24][CH2:25][CH2:26][OH:27]>C(Cl)(Cl)Cl>[OH:27][CH2:26][CH2:25][CH2:24][NH:23][C:8]([O:10][CH2:11][CH2:12][S:13][C:14]1[N:19]2[CH:20]=[CH:21][N:22]=[C:18]2[CH:17]=[CH:16][CH:15]=1)=[O:9]

참가 물질

4

반응물 2

HCID 90863-Amino-1-propanolHCID 233628305-[2-(Phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine

생성물 1

HCID 233628315-[2-[3-(Hydroxy)propylcarbamoyloxy]ethylthio]imdazo[1,2-a]pyridine수율 55.6%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
120 °C

실험 절차

To 5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine (1.10 g, 3.50 mmoles) was added 3-aminopropanol (0.27 ml, 3.52 mmoles) and the mixture was stirred at 120° C. for 1.5 hours. The reaction mixture was cooled by standing and chloroform was added thereto, which was washed with water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 575 mg of the desired product (55.6%, colorless crystals).

후처리

  1. temperatureThe reaction mixture was cooled
  2. washwhich was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off
  5. customThen, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20)

출처 및 근거

ORD 기록
ord-349268ab472d46378b63207ed9f22d8d
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244908

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