Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetic acid → n-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-cyanoacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetic acid | HCID 9740 | — |
| 반응물 | 5,6-diamino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione hydrate | HCID 12257483 | — |
| 생성물 | n-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-cyanoacetamide | HCID 225212 | — |
반응 단계
5,6-Diamino-1,3-dimethyluracil hydrate is reacted with cyanoacetic acid to yield 5-cyanoacetamido-6-amino-1,3-dimethyluracil of the formula: ##STR4## The 5-cyanoacetamido-6-amino-1,3-dimethyluracil is treated with sodium hydroxide within a temperature range of 145°-155° C. to yield 8-carboxymethyltheophylline of the formula: ##STR5## The 8-carboxymethyltheophylline is treated with an alkylated inhibitor of the formula: ##STR6## to yield the compounds of formula (II).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04451652 |
| 출처 데이터셋 | uspto-grants-1984_05 |
| ORD ID | ord-bf5e700217ec4aa796a4937debfc30b6 |
| 출처 메모 | uspto-grants-1984_05 |