Bromine → 2-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide

HRID 54511노트

반응식

HRID 54511 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][N:5]=1)(=[O:3])[CH3:2].[Br:11]Br>Br>[BrH:11].[Br:11][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][N:5]=1)=[O:3]

참가 물질

4

반응물 2

HCID 24408BromineHCID 101541661-(5-Chloropyridin-2-yl)ethan-1-one

생성물 1

HCID 199594142-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide

시약·촉매·용매 1

HCID 260Hydrogen Bromide용매2회

실험 절차

To a solution of 10 g of 2-acetyl-5-chloropyridine in 150 ml of 48% aqueous hydrobromic acid are added 4 ml of bromine dissolved in 40 ml of hydrobromic acid, with stirring, drop by drop, at 80°. The mixture is stirred for additionally 3 hours at 80°. Afterwards the solution is evaporated in vacuo. The residue is triturated with acetone, filtered by suction, washed with acetone and dried in vacuo to yield yellow crystals of the compound, which is used for the next step without purification.

후처리

  1. customat 80°
  2. stirringThe mixture is stirred for additionally 3 hours at 80°
  3. customAfterwards the solution is evaporated in vacuo
  4. customThe residue is triturated with acetone
  5. filtrationfiltered by suction
  6. washwashed with acetone
  7. customdried in vacuo
  8. customto yield yellow crystals of the compound, which
  9. customis used for the next step without purification

출처 및 근거

ORD 기록
ord-ffec2a69c7414369a7fcdc2f76a7b02f
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622982

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