Imidazole → HCID 19959422, 화합물

HRID 54512

반응식

HRID 54512 반응식
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][N:7]=1)=[O:5].[NH:13]1[CH:17]=[CH:16][N:15]=[CH:14]1>ClCCl>[N:13]1([CH2:3][C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][N:7]=2)=[O:5])[CH:17]=[CH:16][N:15]=[CH:14]1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 199594142-Bromo-1-(5-chloropyridin-2-yl)ethan-1-one hydrobromide

생성물 1

HCID 19959422HCID 19959422, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

15 g of 2-bromoacetyl-5-chloropyridine hydrobromide are dissolved in 50 ml of dry dichloromethane, 9.7 g of imidazole are added and the mixture is stirred for 24 hours at room temperature. Evaporation of the solvent in vacuo and subsequent chromatography of the residue over silicagel (dichloromethane/methanol/heptane=7/1/4) yield the compound as a cream coloured solid; m.p.: 122°-129°.

후처리

  1. customEvaporation of the solvent in vacuo and subsequent chromatography of the residue over silicagel (dichloromethane/methanol/heptane=7/1/4)
  2. customyield the compound as a cream

출처 및 근거

ORD 기록
ord-d144c05ae6ae4a7bbc14d81edc48c273
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622982

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