Lithium azide → 1-Azido-1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

HRID 54515

반응식

HRID 54515 반응식
Cl[CH:2]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1.[N-:16]=[N+:17]=[N-:18].[Li+]>CN(C)C=O>[N:16]([CH:2]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][N:10]=1)[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[CH:5]1)=[N+:17]=[N-:18]

참가 물질

4

반응물 2

HCID 88163Lithium azideHCID 199594231-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

생성물 1

HCID 199594151-Azido-1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.92 g of 1-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane are added under argon to a solution of 0.37 g of lithium azide in 2 ml of dry dimethylformamide and the reaction mixture is stirred at 60° for 18 hours. Working up according to process A (see Example 1) gives the substance as a yellowish oil.

후처리

  1. customgives the substance as a yellowish oil

출처 및 근거

ORD 기록
ord-a1872d4c2faa42f194f06d6f8cbe80f7
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622982

연결된 노트

불러오는 중…