2-Nitrophenol → Benzyl 2-nitrophenyl ether

HRID 54521

반응식

HRID 54521 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([O-:3])=[O:2].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:11]([O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 69472-NitrophenolHCID 7498Benzyl BromideHCID 11430Potassium Carbonate

생성물 1

HCID 736266Benzyl 2-nitrophenyl ether

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A stirred mixture of 2-nitrophenol (13.9 g, 0.10 mol), benzyl bromide (12.0 ml, 0.10 mol) and anhydrous potassium carbonate (30 g, 0.22 mol) in acetone (200 ml) is heated under reflux for 16 hours, cooled, poured onto ice-dilute hydrochloric acid, and extracted with dichloromethane. The extract is dried and evaporated and the residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. temperaturecooled
  4. additionpoured onto ice-dilute hydrochloric acid
  5. extractionextracted with dichloromethane
  6. customThe extract is dried
  7. customevaporated
  8. customthe residue is crystallized from ether-hexane as pale crystals, m.p. <50° C.

출처 및 근거

ORD 기록
ord-e44dbfde469446e78ff3839f598915a5
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622969

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