Sodium Hydroxide → 1-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

HRID 545211노트

반응식

HRID 545211 반응식
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][N:11]=[C:12]2[CH:15]2[CH2:17][CH2:16]2)=[C:7]([O:18][CH3:19])[CH:6]=1)=[O:4].[OH-].[Na+]>C1COCC1.CO>[CH:15]1([C:12]2[C:13]3[C:8](=[C:7]([O:18][CH3:19])[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:14]=3)[CH:9]=[CH:10][N:11]=2)[CH2:16][CH2:17]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 57440910Methyl 1-cyclopropyl-5-methoxyisoquinoline-7-carboxylate

생성물 1

HCID 574408921-Cyclopropyl-5-methoxyisoquinoline-7-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

1-Cyclopropyl-5-methoxy-isoquinoline-7-carboxylic acid methyl ester (4.87 g, 18.9 mmol) was dissolved in THF (50 ml) and MeOH (50 ml), and 5N NaOH aq. (18.9 ml) was added thereto. After stirred at 60° C. for 2 h, the mixture was concentrated in vacuo. The residue was triturated with H2O and 5N HCl aq. (18.9 ml) and the insoluble solid was collected through filtration to obtain the intended compound as a colorless solid.

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was triturated with H2O and 5N HCl aq. (18.9 ml)
  3. filtrationthe insoluble solid was collected through filtration

출처 및 근거

ORD 기록
ord-1e68417dd62749e19a7bc8698d5a89a8
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935712B2

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