Indole → 7-(Benzyloxy)-1H-indole

HRID 54522

반응식

HRID 54522 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C([O:13][CH2:14][CH3:15])(=O)C>[Ni].C(O)C>[CH2:14]([O:13][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:9]=1[NH:1][CH:2]=[CH:3]2)[C:15]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 798IndoleHCID 8857Ethyl Acetate

생성물 1

HCID 2607987-(Benzyloxy)-1H-indole

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

Wet Raney nickel is added in portions to a stirred refluxing solution of 7-(benzyloxy)-3-methylthio)indole (4.0 g, 14.9 mmol) in ethyl acetate (100 ml) and ethanol (60 ml) until all the starting material has been consumed (by RP HPLC). The mixture is filtered, the filtrate evaporated and the residue chromatographed on silica in ethyl acetate-hexane (1:8) to give a pale oil.

후처리

  1. customhas been consumed (by RP HPLC)
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. customthe residue chromatographed on silica in ethyl acetate-hexane (1:8)
  5. customto give a pale oil

출처 및 근거

ORD 기록
ord-1390f576f6564c378bf76d8f0a770020
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622969

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