Dimethyl Sulfoxide → 1-(2-Ethoxyethyl)-4-(2-methyl-4-nitrophenyl)piperazine

반응식

[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:2].[N+:12]([C:15]1[CH:20]=[CH:19][C:18](F)=[CH:17][CH:16]=1)([O-:14])=[O:13].[CH3:22]S(C)=O>>[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:18]2[CH:19]=[CH:20][C:15]([N+:12]([O-:14])=[O:13])=[CH:16][C:17]=2[CH3:22])[CH2:10][CH2:11]1)[CH3:2]

참가 물질

반응물 3

HCID 679Dimethyl Sulfoxide

HCID 9590p-Fluoronitrobenzene

HCID 27346431-(2-Ethoxyethyl)piperazine

생성물 1

HCID 671717551-(2-Ethoxyethyl)-4-(2-methyl-4-nitrophenyl)piperazine

실험 절차

In the same manner as in Production Example 5-1, but using 4-(2-ethoxyethyl)piperazine in place of N-ethylpiperazine used in Production Example 5-1, using 4-nitrofluorobenzene in place of 2-fluoro-5-nitrobenzyl alcohol, and using dimethylsulfoxide in place of N-methylpyrrolidone, 1.50 g of the entitled compound was obtained as a yellow solid.

출처 및 근거

ORD 기록: ord-065667ded40b4a6ab17689ef360b5e8c
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07935708B2

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