Ammonium Chloride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 545250노트

반응식

HRID 545250 반응식
[BH4-].[Na+].[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[N:7]=1)(=[O:5])[CH3:4].[Cl-].[NH4+]>C(O)C>[Br:12][C:8]1[N:7]=[C:6]([CH:3]([OH:5])[CH3:4])[CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

생성물 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanol수율 100.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

With cooling with ice, 426 mg of sodium borohydride was added to ethanol (50 mL) solution of 4.50 g of 2-acetyl-6-bromopyridine. After stirred for 1 hour, aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, 4.58 g of the entitled compound was obtained as a colorless oily substance.

후처리

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationAfter concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0473f1e63db4488d879b1076ef22b2cb
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935708B2

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