Sodium Hydroxide → 3-Cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid

HRID 545345노트

반응식

HRID 545345 반응식
C([O:3][C:4]([C:6]1[N:7]([CH:29]2[CH2:31][CH2:30]2)[C:8]([C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][CH:19]=2)=[N:9][C:10]=1[C:11]1[CH:12]=[N:13][C:14]([OH:17])=[CH:15][CH:16]=1)=[O:5])C.[OH-].[Na+]>CCO>[CH:29]1([N:7]2[C:6]([C:4]([OH:5])=[O:3])=[C:10]([C:11]3[CH:12]=[N:13][C:14]([OH:17])=[CH:15][CH:16]=3)[N:9]=[C:8]2[C:18]2[CH:23]=[CH:22][C:21]([O:24][C:25]([F:27])([F:28])[F:26])=[CH:20][CH:19]=2)[CH2:31][CH2:30]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 178468520HCID 178468520, 화합물

생성물 1

HCID 1785240453-Cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid수율 95.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 0.8 g (1.8 mmol) of 3-cyclopropyl-5-(6-hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-3H-imidazole-4-carboxylic acid ethyl ester in 3 ml of EtOH was added 0.6 ml of 6 M sodium hydroxide solution (3.8 mmol) and the mixture was heated to reflux for 16 h. The solvent was then evaporated, 1M hydrochloric acid solution was added and the resulting precipitate was isolated by filtration, affording 0.7 g (94%) of the title compound as a white solid. MS: 406.1 (MH+).

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 16 h
  3. customThe solvent was then evaporated
  4. addition1M hydrochloric acid solution was added
  5. customthe resulting precipitate was isolated by filtration

출처 및 근거

ORD 기록
ord-45b47bf50a6c4deba14b42ec4a0b4789
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935707B2

반응 노트

불러오는 중…