((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride → [2-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-[4-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

HRID 545403

반응식

HRID 545403 반응식
[CH2:1]([C:7]1[CH:8]=[C:9]([C:13]2[N:17]([CH3:18])[C:16]([C:19]([OH:21])=O)=[C:15]([I:22])[N:14]=2)[CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].Cl.Cl.[NH:25]1[CH2:30][CH2:29][CH:28]([N:31]2[CH2:35][CH2:34][CH2:33][C@@H:32]2[CH2:36][OH:37])[CH2:27][CH2:26]1>>[CH2:1]([C:7]1[CH:8]=[C:9]([C:13]2[N:17]([CH3:18])[C:16]([C:19]([N:25]3[CH2:26][CH2:27][CH:28]([N:31]4[CH2:35][CH2:34][CH2:33][C@@H:32]4[CH2:36][OH:37])[CH2:29][CH2:30]3)=[O:21])=[C:15]([I:22])[N:14]=2)[CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

3

반응물 2

HCID 67133026((R)-1-Piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride2회HCID 671332392-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazole-4-carboxylic acid2회

생성물 1

HCID 57541141[2-(3-Hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-[4-((R)-2-hydroxymethyl-pyrrolidin-1-yl)-piperidin-1-yl]-methanone

실험 절차

In analogy to the procedure described for example 2, 2-(3-hexyl-phenyl)-5-iodo-3-methyl-3H-imidazole-4-carboxylic acid (intermediate 1) and ((R)-1-piperidin-4-yl-pyrrolidin-2-yl)-methanol di-hydrochloride (intermediate 2) gave the title compound as light red amorphous solid. MS: 579.3 (MH+).

출처 및 근거

ORD 기록
ord-8644913ba96e4da29633a33912dcbc58
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935707B2

연결된 노트

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