3-(3-nitro-1H-pyrazol-1-yl)propan-1-ol → 3-(3-amino-1H-pyrazol-1-yl)propan-1-ol
반응식
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][OH:12])[N:5]=1)([O-])=O>O1CCCC1.NN.[Ni]>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][CH2:10][CH2:11][OH:12])[N:5]=1참가 물질
5
실험 절차
To a solution containing 3-(3-nitro-pyrazol-1-yl)-propan-1-ol (72 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (˜100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 3-(3-amino-pyrazol-1-yl)-propan-1-ol as a yellow oil, which was then immediately used in the next step with no further purification.
후처리
- additionwas added to the clear solution
- customafter which time the raney nickel was removed by filtration through a celite plug
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-1afc62dd100c452589fec169a08eb4d5
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07935699B2
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