1-(4-methylbenzyl)-3-nitro-1H-pyrazole → HCID 571039, 화합물

HRID 546030

반응식

HRID 546030 반응식
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[N:8]2)=[CH:4][CH:3]=1>O1CCCC1.NN.[Ni]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]2)=[CH:15][CH:16]=1

참가 물질

5

반응물 1

HCID 70101741-(4-methylbenzyl)-3-nitro-1H-pyrazole

생성물 1

HCID 571039HCID 571039, 화합물

시약·촉매·용매 3

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매2회HCID 9321Hydrazine용매

실험 절차

To a solution containing 1-(4-methyl-benzyl)-3-nitro-1H-pyrazole (92 mg, 0.42 mmol) in tetrahydrofuran (2 mL), anhydrous hydrazine (100 μL) was added to the clear solution. Raney nickel (˜100 mg washed 3 times with 5 mL of anhydrous tetrahydrofuran) was then added in tetrahydrofuran (300 μL). Gas evolved from the mixture and the reaction was allowed to proceed for 5 min, after which time the raney nickel was removed by filtration through a celite plug. The solvent was removed in vacuo to afford 1-(4-methyl-benzyl)-1H-pyrazol-3-ylamine as a yellow oil which was used in the following step with no further purification.

후처리

  1. additionwas added to the clear solution
  2. customafter which time the raney nickel was removed by filtration through a celite plug
  3. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-f11207cfe36b4a66a84f0f32ba581c7f
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935699B2

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