6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline → 3,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH:9]([CH3:15])[NH:8][CH2:7][CH2:6]2.N1C=CC=CC=1.C(OC(=O)C)(=O)C>>[CH3:15][C:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:12]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:7][N:8]=1

참가 물질

반응물 2

HCID 103026,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline

HCID 22348678Acetic anhydride pyridine

생성물 1

HCID 226523,4-Dihydro-6,7-dimethoxy-1-methylisoquinoline

실험 절차

6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline, conversion>99%, ee 82% (GC, sample derivatised by treatment with acetic anhydride pyridine, Chirasil DEX CB, 25 m×0.25 mm, injector/detector 200° C., helium 20 psi, 170° C. for 20 minutes then ramp at 5° C./min to 200° C., hold for 10 minutes, retention times 30.18 minutes and 30.45 minutes).

후처리

customretention times 30.18 minutes and 30.45 minutes

출처 및 근거

ORD 기록: ord-c4b619383e4c49889daed010d1c31a9b
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07935841B2

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