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Hydrochloric Acid → 2-(4-{4,4-Dimethyl-2,5-dioxo-3-[2-(pyridin-3-ylamino)pyridin-4-ylmethyl]imidazolidin-1-yl}-phenyl)-2-methylpropionic acid

HRID 546631
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HRID 546631 반응식
[CH3:1][C:2]1([CH3:36])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([CH3:20])([CH3:19])[C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=2)[C:4](=[O:21])[N:3]1[CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)[CH:24]=1.[OH-].[K+].Cl>CO.O>[CH3:1][C:2]1([CH3:36])[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([CH3:19])([CH3:20])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)[C:4](=[O:21])[N:3]1[CH2:22][C:23]1[CH:28]=[CH:27][N:26]=[C:25]([NH:29][C:30]2[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=2)[CH:24]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 57626005HCID 57626005, 화합물

생성물 1

HCID 576259742-(4-{4,4-Dimethyl-2,5-dioxo-3-[2-(pyridin-3-ylamino)pyridin-4-ylmethyl]imidazolidin-1-yl}-phenyl)-2-methylpropionic acid수율 68.1%

시약·촉매·용매 2

HCID 887Methanol용매
HCID 962
Water
용매

실험 절차

To a solution of 0.34 g of methyl 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoate obtained in stage e) below in 20 mL of methanol, at room temperature, are added 7 mL of 1N potassium hydroxide. The reaction medium is heated at reflux for two hours and concentrated under reduced pressure. The residue obtained is taken up in 10 mL of water and then acidified with 2N HCl to pH=5. The white solid formed is filtered off and then dried to give 0.225 g of 2-[4-(4,4-dimethyl-2,5-dioxo-3-{[2-(pyridin-3-ylamino)pyridin-4-yl]methyl}imidazolidin-1-yl)phenyl]-2-methylpropanoic acid, the characteristics of which are as follows:

후처리

  1. temperatureThe reaction medium is heated
  2. temperatureat reflux for two hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue obtained
  5. customThe white solid formed
  6. filtrationis filtered off
  7. customdried

출처 및 근거

ORD 기록
ord-60e06ad5799544b4931e40ef9dc47edd
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07935819B2

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