Water → 4-(2-(Pyrrolidin-1-yl)ethyl)aniline

HRID 546644노트

반응식

HRID 546644 반응식
O=[C:2]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH2:3][C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[N:11]1([CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([NH2:8])=[CH:9][CH:10]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 167707122-(4-Aminophenyl)-1-(pyrrolidin-1-yl)ethan-1-oneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 64870474-(2-(Pyrrolidin-1-yl)ethyl)aniline수율 101.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1.22 g of 4-(2-oxo-2-pyrrolidin-1-ylethyl)aniline obtained in stage b) below in 100 mL of tetrahydrofuran are added, under argon, 1.1 g of lithium aluminium hydride. The reaction mixture is stirred for one hour at room temperature and then cooled to 0° C. and treated successively with 1.1 mL of water, 1.1 mL of 15% (by weight) sodium hydroxide solution and 3.4 mL of water. The solid formed is filtered off and washed with ethyl acetate, and the filtrate is concentrated under reduced pressure to give 1.15 g of 4-(2-pyrrolidin-1-ylethyl)aniline, the characteristics of which are as follows:

후처리

  1. temperaturecooled to 0° C.
  2. customThe solid formed
  3. filtrationis filtered off
  4. washwashed with ethyl acetate
  5. concentrationthe filtrate is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1a86a24f73e44cefbf9a903e7220bfe8
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935819B2

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