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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Formaldehyde → (8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol

HRID 546663
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인쇄 미리보기

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HRID 546663 반응식
C=O.[H-].[Na+].[F:5][C:6]1[CH:7]=[C:8]([CH:12]2[CH2:17][CH2:16][CH2:15][N:14]3[N:18]=[C:19](/[CH:21]=[CH:22]/[C:23]4[CH:28]=[CH:27][C:26]([N:29]5[CH:33]=[C:32]([CH3:34])[N:31]=[CH:30]5)=[C:25]([O:35][CH3:36])[CH:24]=4)[N:20]=[C:13]23)[CH:9]=[CH:10][CH:11]=1.O.[C:38](=O)(O)[O-:39].[Na+]>CN(C=O)C.C(OCC)(=O)C>[F:5][C:6]1[CH:7]=[C:8]([C:12]2([CH2:38][OH:39])[CH2:17][CH2:16][CH2:15][N:14]3[N:18]=[C:19](/[CH:21]=[CH:22]/[C:23]4[CH:28]=[CH:27][C:26]([N:29]5[CH:33]=[C:32]([CH3:34])[N:31]=[CH:30]5)=[C:25]([O:35][CH3:36])[CH:24]=4)[N:20]=[C:13]23)[CH:9]=[CH:10][CH:11]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 712FormaldehydeHCID 24758Sodium hydrideHCID 25212802HCID 25212802, 화합물HCID 86585896Sodium bicarbonate water

생성물 1

HCID 66839396(8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridin-8-yl)methanol

시약·촉매·용매 2

HCID 6228
Dimethylformamide
용매
HCID 8857Ethyl Acetate용매

실험 절차

Paraformaldehyde (186 mg) and sodium hydride (containing 40% of mineral oil, 28.7 mg) were added to a solution of 8-(3-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine synthesized by the method in Examples 1 and 2 (154 mg) in DMF (3 mL), and the reaction solution was stirred at room temperature for 30 minutes. Thereafter, ethyl acetate and saturated sodium bicarbonate water were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 204 mg of the title compound. The property value of the compound is as follows.

후처리

  1. customthe organic layer was separated
  2. dry with materialThe resulting organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3e354777320b4186bb0a274837d7adda
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07935815B2

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