1-{[(3-Nitroquinolin-4-yl)amino]methyl}cyclopropanol → 1-{[(3-Aminoquinolin-4-yl)amino]methyl}cyclopropanol 1-{[(3-nitroquinolin-yl)amino]methyl}cyclopropanol

HRID 547327노트

반응식

HRID 547327 반응식
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]1([OH:19])[CH2:18][CH2:17]1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-:3])=[O:2]>[Pt].C(OCC)(=O)C.CO>[N+:1]([C:4]1[C:5]([NH:14][CH2:15][C:16]2([OH:19])[CH2:18][CH2:17]2)=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-:3])=[O:2].[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]1([OH:19])[CH2:18][CH2:17]1)=[CH:11][CH:10]=[CH:9][CH:8]=2

참가 물질

5

반응물 1

HCID 574554091-{[(3-Nitroquinolin-4-yl)amino]methyl}cyclopropanol

생성물 1

HCID 672039411-{[(3-Aminoquinolin-4-yl)amino]methyl}cyclopropanol 1-{[(3-nitroquinolin-yl)amino]methyl}cyclopropanol

시약·촉매·용매 3

HCID 23939Platinum촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 1-{[(3-nitroquinolin-4-yl)amino]methyl}cyclopropanol (3.50 g, 13.5 mmol) and 5% platinum on carbon (350 mg) in ethyl acetate (70 mL) and methanol (7 mL) was hydrogenated under 35 psi (2.4×105 Pa) on a Parr apparatus for 3 hours. The mixture was filtered through CELITE filter agent, which was rinsed with ethyl acetate. The filtrate was concentrated under reduced pressure to yield 1-{[(3-aminoquinolin-4-yl)amino]methyl}cyclopropanol 1-{[(3-nitroquinolin-yl)amino]methyl}cyclopropanol an orange oil that was used immediately in the next step.

후처리

  1. filtrationThe mixture was filtered through CELITE
  2. filtrationfilter agent, which
  3. washwas rinsed with ethyl acetate
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5a01477051704c2e8c0bc83926f814e1
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07939526B2

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