N-Benzylacetamide → 3-benzyl-7-chloro-2-methylquinazolin-4(3H)-one

HRID 547452

반응식

HRID 547452 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:12]([NH:19][C:20](=O)[CH3:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>P(Cl)(Cl)(Cl)=O>[CH2:12]([N:19]1[C:4](=[O:6])[C:3]2[C:2](=[CH:10][C:9]([Cl:11])=[CH:8][CH:7]=2)[N:1]=[C:20]1[CH3:21])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 11500N-BenzylacetamideHCID 666462-Amino-4-chlorobenzoic acid

생성물 1

HCID 583781963-benzyl-7-chloro-2-methylquinazolin-4(3H)-one

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

2-Amino-4-chlorobenzoic acid (250 mg, 1 eq.) and N-benzylacetamide (261 mg, 1.2 eq.) were dissolved in phosphorus oxychloride (2 ml). The reaction was placed in the microwave for 10 minutes at 150° C. The reaction was quenched by pouring the mixture into ice. The crude product was extracted into ethyl acetate. The ethyl acetate layer was washed with water, 10% aqueous sodium hydroxide, dried with magnesium sulfate, filtered, and concentrated to yield 3-benzyl-7-chloro-2-methylquinazolin-4 (3H)-one as an orange solid.

후처리

  1. customThe reaction was quenched
  2. additionby pouring the mixture into ice
  3. extractionThe crude product was extracted into ethyl acetate
  4. washThe ethyl acetate layer was washed with water, 10% aqueous sodium hydroxide
  5. dry with materialdried with magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6d9d58d3257b4282bb0988a4d0392c84
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07939539B2

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