4-Fluorothiophenol → Ethanethioic acid trans-(+/-)-S-[5-[[(4-fluorophenyl)thio]methyl]tetrahydro-3-furanyl]ester

HRID 54774

반응식

HRID 54774 반응식
FC(F)(F)S(O[CH2:7][C@@H:8]1[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]1)(=O)=O.CCN(C(C)C)C(C)C.[F:28][C:29]1[CH:34]=[CH:33][C:32]([SH:35])=[CH:31][CH:30]=1>C(Cl)Cl>[F:28][C:29]1[CH:34]=[CH:33][C:32]([S:35][CH2:7][C@@H:8]2[O:12][CH2:11][C@@H:10]([S:13][C:14](=[O:16])[CH3:15])[CH2:9]2)=[CH:31][CH:30]=1

참가 물질

5

반응물 3

HCID 677894-FluorothiophenolHCID 81531DiisopropylethylamineHCID 86750748Ethanethioic acid trans(+/-)-S-[tetrahydro-5-[[[(trifluoromethyl)sulfonyl]oxy]methyl]-3-furanyl]ester

생성물 1

HCID 86750751Ethanethioic acid trans-(+/-)-S-[5-[[(4-fluorophenyl)thio]methyl]tetrahydro-3-furanyl]ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound is prepared by the procedure of Example 23 using 0.308 g of product from Example 22 in 1 ml of methylene chloride, 107 microliter of 4-fluorothiophenol, and 174 microliter of Hunig's base to give 0.236 g of the desired product.

출처 및 근거

ORD 기록
ord-1f1cec4eec9c44a0b79c59d2ea655bfc
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623081

연결된 노트

불러오는 중…