Hydrochloric Acid → Piperidin-4-yl-pyrimidin-5-yl-amine dihydrochloride

HRID 547915

반응식

HRID 547915 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:16]=[N:17][CH:18]=[N:19][CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]2[CH:20]=[N:19][CH:18]=[N:17][CH:16]=2)[CH2:12][CH2:13]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 671982114-(Pyrimidin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 67196781Piperidin-4-yl-pyrimidin-5-yl-amine dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 4-(pyrimidin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.30 g, 4.67 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 179.1 [M+H]+.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

출처 및 근거

ORD 기록
ord-4d30a8df9b104fffb55eb874fa7d86c4
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07939661B2

연결된 노트

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