Ethanol → N-[[(4-Nitrophenyl)methoxy]carbonyl]-L-isoleucine

HRID 54817

반응식

HRID 54817 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12](=[O:23])OC2C=CC([N+]([O-])=O)=CC=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH2:24][C@H:25]([C:30]([OH:32])=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27].C(N(CC)CC)C.C(O)C>O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][O:11][C:12]([NH:24][C@H:25]([C:30]([OH:32])=[O:31])[C@H:26]([CH2:28][CH3:29])[CH3:27])=[O:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

6

반응물 4

HCID 702EthanolHCID 6306L-IsoleucineHCID 8471TriethylamineHCID 21829967Carbonic acid 4-Nitrophenyl (4-Nitrophenyl)methyl Ester

생성물 1

HCID 12184447N-[[(4-Nitrophenyl)methoxy]carbonyl]-L-isoleucine수율 24.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound is prepared by the procedure of Example 255 using 14.73 g of product from Example 254, 6.07 g of L-isoleucine, 12.73 ml of triethylamine and 556 ml of 4:1 ethyl alcohol:water to give 3.52 g of the desired product.

출처 및 근거

ORD 기록
ord-1849cdd34ca7460f86457d497ba7c0d0
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623081

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