Ethylene Glycol → 1,4-Dioxa-8-thiaspiro(4.5)decane

HRID 54831

반응식

HRID 54831 반응식
[S:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH2:8](O)[CH2:9][OH:10].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[O:10]1[C:4]2([CH2:5][CH2:6][S:1][CH2:2][CH2:3]2)[O:7][CH2:8][CH2:9]1

참가 물질

6

반응물 4

HCID 174Ethylene GlycolHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 66173Tetrahydrothiopyran-4-one

생성물 1

HCID 123359781,4-Dioxa-8-thiaspiro(4.5)decane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5.0 g of tetrahydrothiopyran-4-one, 2.5 ml of ethylene glycol, 0.230 g of p-toluenesulfonic acid and 125 ml of benzene is stirred at reflux temperature for 2.5 hours. The water formed is removed using a Dean-Stark trap. The reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride, dried and concentrated in vacuo to give 6.52 g of the desired product as an oil.

후처리

  1. temperatureat reflux temperature for 2.5 hours
  2. customis removed
  3. additionThe reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride
  4. customdried
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3e940006c8d94ab8a3f705c659dcaa0b
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05623081

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