3-Chloroaniline → Methanimidamide, N'-(3-chlorophenyl)-N,N-dimethyl-

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH:14]=[N:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)[CH3:13]

참가 물질

반응물 2

HCID 79323-Chloroaniline

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 415383Methanimidamide, N'-(3-chlorophenyl)-N,N-dimethyl-수율 100.5%

실험 절차

A mixture of 3-chloroaniline (63.8 g, 0.50 mol) and dimethylformamide dimethyl acetal (106 ml, 0.75 mol) was heated at 100° for 2 h and evaporated at 60° at 0.5 mm Hg to give 91.8 g amber oil; ms 183.0 (M+H)+.

후처리

temperaturewas heated at 100° for 2 h
customevaporated at 60° at 0.5 mm Hg

출처 및 근거

ORD 기록: ord-39ce25f3d8bb4aeda4ce9dd1583f6e98
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: USRE042376E1

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