Hydrochloric Acid → 4-Chloro-3-mercapto-2-methylbenzoic acid
반응식
[OH-].[K+].[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[C:6]([CH3:14])[C:5]=1[S:15]C(N(C)C)=O.O.Cl>CO>[Cl:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[C:6]([CH3:14])[C:5]=1[SH:15]참가 물질
6
실험 절차
6.61 g (purity 85% by weight, 100.1 mmol) of KOH were added to 4.80 g (16.7 mmol) of methyl 4-chloro-3-(dimethylaminocarbonylthio)-2-methylbenzoate in 150 ml of methanol, and the mixture was stirred under reflux for two days. The reaction mixture was freed from solvent, water was added to the residue, which was then acidified with 1M HCl, and the solid was collected by filtration. This gave 3.2 g of pure product.
후처리
- temperatureunder reflux for two days
- additionwas added to the residue, which
- filtrationthe solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-aa83821db1ab4b92898a4d5ba1be772c
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07943551B2
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