Tetrahydrofuran → 3-Benzyloxy-5-isopropoxybenzoic acid

HRID 548692노트

반응식

HRID 548692 반응식
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:14]=1)[C:8]([O:10]C)=[O:9])[CH3:3].C1COCC1.[OH-].[Na+]>CO>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[C:7]([CH:12]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:14]=1)[C:8]([OH:10])=[O:9])[CH3:1]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 59127144Methyl 3-(benzyloxy)-5-isopropoxybenzoate

생성물 1

HCID 534011033-Benzyloxy-5-isopropoxybenzoic acid수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 3-[(1-methylethyl)oxy]-5-[(phenylmethyl)oxy]benzoate (37 g) in a 1:1 mixture of THF:methanol (300 mL) was added 4M sodium hydroxide solution (150 mL). The mixture was refluxed for 45 minutes, following which the organics were removed in vacuo. The aqueous was acidified to pH4 with hydrochloric acid (2M), and extracted with ethyl acetate. The organics were combined, washed with water and brine, dried (MgSO4) and concentrated in vacuo to give the desired compound (33.5 g), which was used without further purification.

후처리

  1. temperatureThe mixture was refluxed for 45 minutes
  2. customorganics were removed in vacuo
  3. extractionextracted with ethyl acetate
  4. washwashed with water and brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6ab3425b7cb84b93a4a5eb488ded14fc
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943607B2

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