Phenylglycine nitrile → 1H-Indazole-3-carbonitrile

HRID 549067

반응식

HRID 549067 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].[N:11]([O-])=O.[Na+]>Cl>[C:5]([C:4]1[C:3]2[C:2](=[CH:10][CH:9]=[CH:8][CH:7]=2)[NH:1][N:11]=1)#[N:6]

참가 물질

4

반응물 2

HCID 76307Phenylglycine nitrileHCID 23668193Sodium Nitrite

생성물 1

HCID 4375561H-Indazole-3-carbonitrile

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of o-aminobenzyl cyanide (0.5 g) in aqueous hydrochloric acid 1N (9.6 mL), was treated with a solution of aqueous sodium nitrite 1N (3.85 mL). After stirring at room temperature for 15 minutes, the reaction mixture was filtered. The solid was recrystallised from ethanol to give the title compound (0.4 g) as a yellow solid, m.p. 138-140° C. 1H NMR [(CD3)2SO]: δ 7.89 (d, 1H, J=7.7 Hz); 7.76 (d, 1H, J=7.9 Hz); 7.48 (t, 1H); 7.41 (t, 1H).

후처리

  1. filtrationthe reaction mixture was filtered
  2. customThe solid was recrystallised from ethanol

출처 및 근거

ORD 기록
ord-99b2645688ee40448ec16adfb554ec7a
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943616B2

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