Hydrazine hydrate (1:1) → 6-(s-Triazolo[4,3-a]pyridin-3-ylthio)hexylamine

HRID 54917노트

반응식

HRID 54917 반응식
[N:1]1[N:2]=[C:3]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N:17]2C(=O)C3=CC=CC=C3C2=O)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.O.NN>C(O)C>[N:1]1[N:2]=[C:3]([S:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 19956977HCID 19956977, 화합물

생성물 1

HCID 199569956-(s-Triazolo[4,3-a]pyridin-3-ylthio)hexylamine수율 87.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of N-[6-(s-triazolo[4,3-a]pyridin-3-ylthio)hexyl]phthalimide (16.5 g), hydrazine monohydrate (4.34 g) and ethanol (135 ml) was heated under reflux for 1 hour. The deposited crystals were separated by filtration, and the filtrate was concentrated under reduced pressure to obtain 6-(s-triazolo[4,3-a]pyridin-3-ylthio)hexylamine as an oil. Yield: 87.5%.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. customThe deposited crystals were separated by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8dd4f6880f55484eb55f6522407ce1b0
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624917

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