Thionyl Chloride → (6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

HRID 549223노트

반응식

HRID 549223 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14]O)[C:10]#[N:11])=[CH:4][CH:3]=1.S(Cl)([Cl:18])=O>N1C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14][Cl:18])[C:10]#[N:11])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 86624867(6-Chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile

생성물 1

HCID 86624866(6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

시약·촉매·용매 2

HCID 1049Pyridine촉매HCID 6212Chloroform용매

실험 절차

This compound was prepared in a manner analogous to that set forth in Step C of Example 1, using 5.7 grams (0.0255 mole) of 2-{[(6-chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile 3.2 grams (0.0268 mole) of thionyl chloride and one drop (catalyst) of pyridine in 50 mL of chloroform. The yield of the subject compound was 6.0 grams. The NMR spectrum was consistent with the proposed structure.

후처리

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 1

출처 및 근거

ORD 기록
ord-58378f85ee644cb2850e5714cffc67a6
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07943642B2

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