Water → 2-(4-Fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

HRID 54935

반응식

HRID 54935 반응식
[Na].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.[C:12](OCC)(=[O:19])[C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1.O>C(O)C>[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:12](=[O:19])[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)[C:10]#[N:11])=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 15291Ethyl isonicotinateHCID 68016Benzeneacetonitrile, 4-fluoro-HCID 5360545Sodium

생성물 1

HCID 141952232-(4-Fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium (2.48 g) was dissolved in dry ethanol (37 ml) under nitrogen atmosphere. To the solution was added 4-fluorophenylacetonitrile (11.65 g) and ethyl isonicotinate (16.41 ml) and the solution was refluxed for 3 hours. The reaction mixture was cooled and poured into water. The ethanol of the mixture was removed under reduced pressure. The resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid. The separated solid was collected, washed with water and dried to give 2-(4-fluorophenyl)-3-oxo-3-(pyridin-4-yl)propanenitrile (16.43 g).

후처리

  1. temperaturethe solution was refluxed for 3 hours
  2. temperatureThe reaction mixture was cooled
  3. customThe ethanol of the mixture was removed under reduced pressure
  4. washThe resulting aqueous solution was washed with ether and neutralized with diluted hydrochloric acid
  5. customThe separated solid was collected
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-cd938b8859464c00a385acb447f30528
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624931

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