Diethyl Ether → N-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenamide

HRID 5496

반응식

HRID 5496 반응식
[C:1](Cl)(=[O:4])[CH:2]=[CH2:3].C([N:8]([CH2:11][CH3:12])CC)C.[C:13]12(N)[CH2:19][CH:17]([CH2:18]1)[CH2:16][CH2:15]C2.[CH2:21](OCC)C>>[CH3:21][C:16]1([CH3:15])[CH:12]2[CH2:18][CH:17]1[CH2:19][CH2:13][CH:11]2[NH:8][C:1](=[O:4])[CH:2]=[CH2:3]

참가 물질

5

반응물 4

HCID 3283Diethyl Ether2회HCID 8471TriethylamineHCID 13140Acryloyl chlorideHCID 15730006Bicyclo[3.1.1]heptan-1-amine

생성물 1

HCID 19795927N-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)-2-propenamide

실험 절차

Following the procedure of Example 3, a solution of acryloyl chloride (4.05 ml, 0.05 mole) in ethyl ether (50 ml) was added dropwise to a cold 5° C. mixture of triethylamine (15.3 ml, 0.11 mole) and norpinylamine (6.96; g, 0.05 mole) in ethyl ether (400 ml). The reaction was allowed to warm to room temperature and stirred for 72 hours. The light tan solid was filtered and washed well with ethyl ether. The solvent and triethylamine were removed, leaving the title product as an oily solid. The structure was confirmed by NMR.

후처리

  1. filtrationThe light tan solid was filtered
  2. washwashed well with ethyl ether
  3. customThe solvent and triethylamine were removed

출처 및 근거

ORD 기록
ord-0c853584f40147fcac7748a5dc4bc09f
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244899

연결된 노트

불러오는 중…