Hydrochloric Acid → 2-Benzoyl-4,5-dimethoxybenzoic acid

HRID 54976

반응식

HRID 54976 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[O:11])[O:9][C:7](=[O:8])[C:6]2=[CH:12][C:13]=1[O:14][CH3:15].[C:16]1([Mg]Cl)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Cl-].[NH4+].Cl>C1COCC1>[C:7]([C:6]1[CH:12]=[C:13]([O:14][CH3:15])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:10]([OH:9])=[O:11])(=[O:8])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 6103565,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dioneHCID 178478979HCID 178478979, 화합물

생성물 1

HCID 199571592-Benzoyl-4,5-dimethoxybenzoic acid수율 74.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Thirty grams (0.14 mole) of 4,5-dimethoxyphthalic anhydride was suspended in 300 mL of THF and 87 mL (0.17 mole) of phenylmagnesium chloride in THF was added over two hours. The reaction was stirred at room temperature for 14 hours, refluxed for two hours, cooled and poured into saturated ammonium chloride. The mixture was made acidic with 6N HCl, extracted into chloroform, dried over magnesium sulfate, concentrated to provide 30 g of 2-benzoyl-4,5-dimethoxybenzoic acid.

후처리

  1. temperaturerefluxed for two hours
  2. temperaturecooled
  3. extractionextracted into chloroform
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-43f8f20b41bd492a896d88ca1f42014d
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624922

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