1-(3-Fluorobenzyloxy)-2-methyl-4-nitrobenzene → 3-Methyl-4-[(3-fluorobenzyl)oxy]aniline
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=1[CH3:16].[H][H]>C(O)C.O=[Pt]=O>[CH3:16][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]1[CH:17]=[CH:18][CH:19]=[C:2]([F:1])[CH:3]=1)[NH2:13]참가 물질
5
실험 절차
A mixture of 1-[(3-fluorobenzyl)oxy]-2-methyl-4-nitrobenzene (3.2 g, 12.2 mmol) and PtO2 (320 mg) in ethanol (250 ml) was stirred under an atmosphere of hydrogen (1.2 bar) until completion of the reaction (the reaction being complete when 3 mole equivalents of hydrogen have been reacted). The mixture was then filtered over celite and the solvent evaporated to give 3-methyl-4-[(3-fluorobenzyl)oxy]aniline as a yellow oil (2.83 g, 100%);
후처리
- customhave been reacted)
- filtrationThe mixture was then filtered over celite
- customthe solvent evaporated
출처 및 근거
- ORD 기록
- ord-9efa0effb77745d5a0f2f7e81f956d62
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07947676B2
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