Imatinib → Imatinib Mesylate

HRID 550780

반응식

HRID 550780 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:25]=[CH:26][C:27]([CH2:30][N:31]3[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]3)=[CH:28][CH:29]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:21][C:22]([C:24]2[CH:29]=[CH:28][C:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)=[CH:26][CH:25]=2)=[O:23])=[CH:6][C:7]=1[NH:8][C:9]1[N:10]=[CH:11][CH:12]=[C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[N:19][CH:20]=2)[N:14]=1.[CH3:38][S:39]([OH:42])(=[O:41])=[O:40]

참가 물질

3

반응물 2

HCID 5291ImatinibHCID 6395Methanesulfonic Acid

생성물 1

HCID 123596Imatinib Mesylate

실험 절차

The solution in step-(a) may also be prepared by admixing imatinib base, methanesulfonic acid and the solvent medium to obtain a mixture; and heating the mixture to obtain a solution of imatinib mesylate. In one embodiment, the mixture is heated at a temperature of about 40° C. to about 110° C., and more preferably at about 50° C. to about 80° C.

후처리

  1. customThe solution in step-(a) may also be prepared
  2. customthe solvent medium to obtain a mixture
  3. temperatureand heating the mixture

출처 및 근거

ORD 기록
ord-a4d6e77ffbd24d21a5a697e2ca41ae49
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947699B2

연결된 노트

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