Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylsilane → Ammonium Hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylsilane | HCID 12052 | — |
| 반응물 | Methyl (4-nitro-1H-indol-3-yl)(oxo)acetate | HCID 10243717 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate | HCID 10243182 | — |
반응 단계
To a stirred solution of methyl (4-nitro-1H-indol-3-yl)(oxo)acetate from Step A (563 mg, 2.27 mmol) in TFA (25 mL) at 0° C. was added triethylsilane (0.733 mL, 4.54 mmol). After 90 min, the reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with a gradient of CH2Cl2:MeOH:NH4OH—100:0:0 to 95:4.5:0.5, to give the title compound. MS: m/z=235 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947677B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-9b7b347391f74026b832f9656887d64b |
| 출처 메모 | uspto-grants-2011_05 |