Lithium Hydroxide → 4-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid

HRID 551182

반응식

HRID 551182 반응식
[N:1]1([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][C:9]=2[N+:18]([O-:20])=[O:19])[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7].[OH-:21].[Li+]>CO>[C:2]([CH2:3][O:4][CH2:5][CH2:6][NH:1][C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[N+:18]([O-:20])=[O:19])([OH:21])=[O:7]

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 67049467Methyl 4-(morpholin-3-on-4-yl)-3-nitro-benzoate

생성물 1

HCID 667319084-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

400 mg (1.43 mmol) methyl 4-(morpholin-3-on-4-yl)-3-nitro-benzoate are dissolved in 15 ml of methanol and combined with 4.5 ml (4.5 mmol) 1-molar lithium hydroxide solution. The mixture is stirred for 2 hours at ambient temperature. Then it is evaporated down i. vac., the residue is diluted with water, cooled in the ice bath and acidified with 2-molar hydrochloric acid. After 10 minutes cooling in the ice bath the precipitate formed is filtered off, washed with water until neutral and dried at 50° C. in the drying cupboard.

후처리

  1. customThen it is evaporated down i
  2. addition, the residue is diluted with water
  3. temperaturecooled in the ice bath
  4. temperatureAfter 10 minutes cooling in the ice bath the precipitate
  5. customformed
  6. filtrationis filtered off
  7. washwashed with water until neutral and
  8. customdried at 50° C. in the drying cupboard

출처 및 근거

ORD 기록
ord-831e6abfdeca4178b428165780313e02
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947700B2

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