Sodium hydride → 2-Chloro-4-methyl-6-(3-thienylmethyloxy)pyridine

HRID 55125

반응식

HRID 55125 반응식
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].[Cl:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13](Cl)[N:12]=1>O1CCCC1>[Cl:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([O:7][CH2:6][C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[N:12]=1

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 123570Thiophene-3-methanolHCID 108989972,6-Dichloro-4-methylpyridine

생성물 1

HCID 199574012-Chloro-4-methyl-6-(3-thienylmethyloxy)pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution containing 3-thiophenemethanol (0.78 g, 0.0062×1.1 mol) and sodium hydride (0.26 g, (ca.60% in mineral oil), 0.0062×1.05 mol) in tetrahydrofuran, 2,6-dichloro-4-methylpyridine (1.0 g, 0.0062 mol) was added, and the resultant solution was refluxed for about 1 hour.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-be95cbbb0289473d8b925f0d6908ded9
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624942

연결된 노트

불러오는 중…