1-Methyl-4-piperidinemethanol → Oxo-thiophen-2-yl-acetic acid 1-methyl-piperidin-4-ylmethyl ester

HRID 551374

반응식

HRID 551374 반응식
[O:1]=[C:2]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)[C:3](Cl)=[O:4].[CH3:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][OH:19])[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[CH3:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][O:19][C:3](=[O:4])[C:2](=[O:1])[C:6]2[S:7][CH:8]=[CH:9][CH:10]=2)[CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 2719711-Methyl-4-piperidinemethanolHCID 117451372-Chloro-1-(2-thienyl)-2-oxo-1-ethanone

생성물 1

HCID 67197151Oxo-thiophen-2-yl-acetic acid 1-methyl-piperidin-4-ylmethyl ester

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a solution of oxo-thiophen-2-yl-acetyl chloride (31.5 mmol) at 0 to 5° C. in chloroform (60 ml) is added a solution of (1-Methyl-piperidin-4-yl)-methanol (4.07 g, 31.5 mmol) in chloroform (60 ml), dropwise maintaining the temperature below 5° C. The resulting mixture is stirred for 2 hours at room temperature. Washing with 10% potassium carbonate solution, water and then drying over magnesium sulphate, filtration and evaporation gives the title compound.

후처리

  1. temperaturedropwise maintaining the temperature below 5° C
  2. washWashing with 10% potassium carbonate solution, water
  3. dry with materialdrying over magnesium sulphate, filtration and evaporation

출처 및 근거

ORD 기록
ord-6f24278c3974476eabda72f1179b1dc9
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947730B2

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