Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Isoamyl Nitrite | HCID 8053 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | (3-Amino-2-methylphenyl)methanol | HCID 577175 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester | HCID 67151807 | — |
반응 단계
3-Amino-2-methyl benzyl alcohol (0.82 g, 5.98 mmol), acetic anhydride (1.68 mL, 17.8 mmol), potassium acetate (1.75 g, 17.8 mol), isoamyl nitrite (1.82 mL, 13.7 mmol) and 18-crown-6 (79 mg, 0.3 mmol) in 25 mL CHCl3 were reacted as described in EP99/07620. The crude product was purified by flash chromatography with a gradient from 0-35% ethyl acetate in hexanes to yield acetic acid 1-acetyl-1H-indazol-4-ylmethyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947728B1 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-b5aad79e57074a91ad948f17d033bbb6 |
| 출처 메모 | uspto-grants-2011_05 |