Butylate → 7-Methoxy-1-vinylnaphthalene

HRID 551776

반응식

HRID 551776 반응식
CS(O[CH2:6][CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][CH:9]=1)(=O)=O.[K].CCSC(N(CC(C)C)CC(C)C)=O>O1CCCC1.O>[CH3:19][O:18][C:15]1[CH:16]=[C:17]2[C:12]([CH:11]=[CH:10][CH:9]=[C:8]2[CH:7]=[CH2:6])=[CH:13][CH:14]=1

참가 물질

6

반응물 3

HCID 16181ButylateHCID 5462222PotassiumHCID 190859902-(7-Methoxynaphthalen-1-yl)ethyl methanesulfonate

생성물 1

HCID 445416687-Methoxy-1-vinylnaphthalene

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

The compound obtained in Step A (21.4 mmol) is dissolved in 120 ml of tetrahydrofuran, and potassium tent-butylate (64.2 mmol) is added in small portions. After stirring for 30 minutes at ambient temperature, the reaction mixture is evaporated to dryness. The residue obtained is taken up in 150 ml of water and the aqueous phase is extracted twice with 60 ml of diethyl ether. The organic phase is washed with water, dried over magnesium sulphate, decolourised on vegetable carbon and evaporated. The residue obtained is purified on silica gel (eluant: petroleum ether) to yield the title product in the form of a yellow oil.

후처리

  1. customthe reaction mixture is evaporated to dryness
  2. customThe residue obtained
  3. extractionthe aqueous phase is extracted twice with 60 ml of diethyl ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. customThe residue obtained
  8. customis purified on silica gel (eluant: petroleum ether)

출처 및 근거

ORD 기록
ord-c307d8c7baac4019b1c29cce6b41bdff
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947852B2

연결된 노트

불러오는 중…