Potassium Acetate → N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

HRID 551779노트

반응식

HRID 551779 반응식
[OH:1][CH:2]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH:11]=[CH:10][CH:9]=1)[CH2:3][NH:4][C:5](=[O:7])[CH3:6].C([O-])(=O)C.[K+].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[CH3:19][O:18][C:15]1[CH:16]=[C:17]2[C:12]([CH:11]=[CH:10][CH:9]=[C:8]2[C:2](=[O:1])[CH2:3][NH:4][C:5](=[O:7])[CH3:6])=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 517044Potassium AcetateHCID 44359309HCID 44359309, 화합물HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 44541672N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The compound obtained in Step F (7.7 mmol) is dissolved in 200 ml of anhydrous dichloromethane. The resulting solution is added to a suspension of potassium acetate (0.23 g) and pyridinium chlorochromate (11.6 mmol) in 50 ml of dichloromethane. The reaction mixture is stirred at ambient temperature for 2 hours. It is then filtered over Celite. The filtrate is washed with water, decolourised on vegetable carbon and evaporated under reduced pressure. The residue obtained is triturated in diethyl ether, filtered off under suction and recrystallised from diisopropyl ether to yield the title product in the form of a white solid.

후처리

  1. filtrationIt is then filtered over Celite
  2. washThe filtrate is washed with water
  3. customevaporated under reduced pressure
  4. customThe residue obtained
  5. customis triturated in diethyl ether
  6. filtrationfiltered off under suction
  7. customrecrystallised from diisopropyl ether

출처 및 근거

ORD 기록
ord-3d8f6233a57d498eb66559249da66e91
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947852B2

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