Water → 9,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

HRID 55178노트

반응식

HRID 55178 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[O:7]1[C:11]2[NH:12][C:13](=O)[C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1.O.[OH-].[Na+]>O1CCCC1>[O:7]1[C:11]2[NH:12][CH2:13][C:14]3[N:15]([CH:17]=[CH:18][CH:19]=3)[CH2:16][C:10]=2[CH:9]=[CH:8]1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 100133324,10-dihydro-9H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-oneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 218369669,10-Dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 4 mmol of lithium aluminum hydride in 25 ml of anhydrous tetrahydrofuran is added 1 mmol of 9,10-dihydro-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-9-one. The mixture is refluxed for 12 hours and allowed to stand overnight. To the mixture is added dropwise 0.12 ml of water and then 6 ml of 1N sodium hydroxide. The mixture is extracted with ethyl acetate and the extract dried(Na2SO4). The volatiles are removed in vacuo to give the desired product as a solid.

후처리

  1. temperatureThe mixture is refluxed for 12 hours
  2. extractionThe mixture is extracted with ethyl acetate
  3. customThe volatiles are removed in vacuo

출처 및 근거

ORD 기록
ord-4762298b84da4cbe84a0b5ee1d200f6a
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624923

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