Water → HCID 72702564, 화합물

HRID 551780노트

반응식

HRID 551780 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[C:13](=O)[CH2:14][NH:15][C:16](=[O:18])[CH3:17])=[CH:5][CH:4]=1.Cl.[NH2:21][OH:22].N1C=CC=CC=1.O>CO>[OH:22]/[N:21]=[C:13](/[C:10]1[C:11]2[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=2)[CH:7]=[CH:8][CH:9]=1)\[CH2:14][NH:15][C:16](=[O:18])[CH3:17]

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 44541672N-[2-(7-Methoxy-1-naphthyl)-2-oxoethyl]acetamide

생성물 1

HCID 72702564HCID 72702564, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a 100-ml round-bottom flask, the compound obtained in Step G (4.2 mmol) is dissolved in 25 ml of methanol. Hydroxylamine hydrochloride (16.8 mmol) and pyridine (21.1 mmol) are added and then the reaction mixture is heated at reflux, with magnetic stirring, for 3 hours. After cooling, the reaction mixture is poured into 50 ml of water. The precipitate formed is filtered off under suction, washed with water and recrystallised from toluene to yield the title product in the form of a white solid.

후처리

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux, with magnetic stirring, for 3 hours
  3. temperatureAfter cooling
  4. customThe precipitate formed
  5. filtrationis filtered off under suction
  6. washwashed with water
  7. customrecrystallised from toluene

출처 및 근거

ORD 기록
ord-8dac76ab604f4edaa3ff083e43e822ab
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947852B2

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