Hydrochloric Acid → {4-[(3-(Pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol Hydrochloride
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:11][CH2:10][N:9]([C:12]([N:14]3[C:19]4[CH:20]=[C:21]([CH2:24][OH:25])[CH:22]=[CH:23][C:18]=4[O:17][CH2:16][CH2:15]3)=[O:13])[CH2:8]2)[CH:2]=1.[ClH:26]>CCOCC>[ClH:26].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[CH2:11][CH2:10][N:9]([C:12]([N:14]3[C:19]4[CH:20]=[C:21]([CH2:24][OH:25])[CH:22]=[CH:23][C:18]=4[O:17][CH2:16][CH2:15]3)=[O:13])[CH2:8]2)[CH:2]=1참가 물질
4
실험 절차
0.21 g of {4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol, dissolved in 6.19 ml of a 0.1N solution of hydrochloric acid in ether, is introduced into a 50 ml round-bottomed flask. Stirring is maintained for ten minutes. After evaporating, the residue is triturated in ethyl ether and then the solid is filtered off in order to obtain, after drying under vacuum, 0.108 g of {4-[(3-(pyridin-3-yl)pyrrolidin-1-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-6-yl}methanol hydrochloride.