Hydrochloric Acid → 4-Difluoromethylene-1,2,3,4-tetrahydroquinoline
반응식
[F:1][C:2]([F:21])=[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6](NC(OC(C)(C)C)=O)[CH2:5][CH2:4]1.Cl>ClCCl.O1CCOCC1>[F:21][C:2]([F:1])=[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH2:5][CH2:4]1참가 물질
5
실험 절차
0.11 g of tert-butyl 4-difluoromethylene-3,4-dihydro-2H-quinoline-1-carbamate in 10 ml of dichloromethane is introduced into a round-bottomed flask equipped with a magnetic stirrer. 6 ml of a 4N solution of hydrochloric acid in dioxane are added. After stirring at ambient temperature for 6 h, the reaction medium is concentrated under vacuum. 0.07 g of 4-difluoromethylene-1,2,3,4-tetrahydroquinoline is obtained.
후처리
- customequipped with a magnetic stirrer
- concentrationthe reaction medium is concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-c8c833fb7b7c40809e09c89c00275c69
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07947834B2
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